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European Directorate for the Quality of Medicines and HealthCare
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Becton Dickinson
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BIOFARMA Pharmaceutical
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Titan Biotech Ltd
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BIOFARMA Pharmaceutical
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Clinical and Laboratory Standards Institute
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Blackwell Verlag
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Informa UK Limited
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Nabriva Therapeutics
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Pfizer Inc
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Image Search Results
Journal: Drug testing and analysis
Article Title: Evaluation of impurities and dissolution profiles of illegal antimicrobial drugs encountered in Belgium.
doi: 10.1002/dta.2690
Figure Lengend Snippet: FIGURE 2 Mean dissolution profiles of 12 genuine products (code starting with G) and 19 illegal samples (code starting with I). A, amoxicillin of co‐amoxiclav (500 mg/125 mg); B, clavulanic acid of co‐amoxiclav (500 mg/125 mg); C, amoxicillin of co‐amoxiclav (875 mg/125 mg); D, clavulanic acid of co‐amoxiclav (875 mg/125 mg); E, amoxicillin 500 mg; F. azithromycin 250 mg; G, azithromycin 500 mg; H. sulfamethoxazole of co‐ trimoxazole (800 mg/160 mg); I, trimethoprim of co‐trimoxazole (800 mg/160 mg) [Colour figure can be viewed at wileyonlinelibrary.com]
Article Snippet:
Techniques: Dissolution
Journal: Journal of Translational Medicine
Article Title: Azithromycin is able to control Toxoplasma gondii infection in human villous explants
doi: 10.1186/1479-5876-12-132
Figure Lengend Snippet: Analysis of cytotoxicity in human villous explants. Villous explant supernatants were collected and lactate dehydrogenase (LDH) activity was measured using the LDH Liquiform kit. The positive control was established by adding 0.2% Triton X-100 (A) . Human villous explants were infected or not by T. gondii and treated with increasing concentrations of azithromycin or PSA for 24 h and the percentage of tissue toxicity was analyzed (B) . Data are expressed as mean ± SEM. Significant differences were analyzed by ANOVA and Bonferroni multiple comparison post hoc test. *** P < 0.001 in relation to the positive control; ΦΦ P < 0.01 between uninfected and infected villous explants.
Article Snippet:
Techniques: Activity Assay, Positive Control, Infection, Comparison
Journal: Journal of Translational Medicine
Article Title: Azithromycin is able to control Toxoplasma gondii infection in human villous explants
doi: 10.1186/1479-5876-12-132
Figure Lengend Snippet: T. gondii intracellular proliferation in villous explants treated with azithromycin or PSA. Villous explants were infected and treated for 72 h with azithromycin or PSA at different concentrations. T. gondii proliferation was measured by a colorimetric β-galactosidase assay (A) . The bars represent mean ± SEM. Data were analyzed by ANOVA and Bonferroni multiple comparison post hoc test. Significant differences in comparison with untreated villous explants are labeled ( *** P < 0.001; ** P < 0.01). Representative photomicrographs of human villous explants infected or not with T. gondii : uninfected human villous explants as a negative control (B) , arrows indicate tachyzoites in untreated human villous explants (C) , azithromycin-treated (D) and PSA-treated (E) human villous explants. Arrowheads indicate syncytiotrophoblast layers, and M indicates mesenchymal tissue. Counterstaining with Mayer’s hematoxylin was performed. Scale bar: 10 μm.
Article Snippet:
Techniques: Infection, Comparison, Labeling, Negative Control
Journal: Journal of Translational Medicine
Article Title: Azithromycin is able to control Toxoplasma gondii infection in human villous explants
doi: 10.1186/1479-5876-12-132
Figure Lengend Snippet: Cytokine production by T. gondii -infected villous explants after treatment with azithromycin or PSA. Supernatants of villous explants were collected after 24 h of treatment and production of TNF-α (A) , IL-17A (B) , TGF-β1 (C) , IL-10 (D) , IL-12 (E) and IL-6 (F) were measured by a CBA or ELISA. The continuous line represents the parasite load. Data are expressed as mean ± SEM. Data were analyzed by ANOVA and Bonferroni multiple comparison post hoc test. ### P < 0.001; ## P < 0.01 and # P < 0.05 in relation to NT control.
Article Snippet:
Techniques: Infection, Enzyme-linked Immunosorbent Assay, Comparison, Control
Journal: Journal of Translational Medicine
Article Title: Azithromycin is able to control Toxoplasma gondii infection in human villous explants
doi: 10.1186/1479-5876-12-132
Figure Lengend Snippet: Detection of sex hormones and parasite load in uninfected and T. gondii -infected villous explants, treated or not with azithromycin or PSA. Estradiol (A) , progesterone (B) and HCG + β (C) were measured by an electrochemiluminescence immunoassay of uninfected or T. gondii- infected villous explants. Levels of (D) estradiol, (E) progesterone, and (F) HCG + β in azithromycin- or PSA-treated or untreated villous explants were analyzed in relation to parasite load. Data were analyzed by ANOVA and Bonferroni multiple comparison post hoc test. Comparisons are represented by symbols: parasitism, *** P < 0.001, ** P < 0.01, * P < 0.05 and sexual hormones, ### P < 0.001, ## P < 0.01, # P < 0.05 in relation to NT control.
Article Snippet:
Techniques: Infection, Electrochemiluminescence, Comparison, Control
Journal: Journal of Translational Medicine
Article Title: Azithromycin is able to control Toxoplasma gondii infection in human villous explants
doi: 10.1186/1479-5876-12-132
Figure Lengend Snippet: T. gondii intracellular proliferation in villous explants infected with pretreated (azithromycin or PSA) parasites. Proliferation was measured by a colorimetric β-galactosidase assay. The bars represent mean ± SEM. Data were analyzed by ANOVA and Bonferroni multiple comparison post hoc test. *** P < 0.001, ** P < 0.01 and * P < 0.05 in relation to NTp control. Φ Comparison between villous explants treated with different concentrations of azithromycin (P < 0.05).
Article Snippet:
Techniques: Infection, Comparison, Control